А novel cationic chitosan derivative, N-[4-(N, N, N-trimethylammonium) benzyl] chitosan
chloride (TMAB-CS), with different degrees of substitution (DS) was synthesized by a …

Recently, much effort has been expended on the development of non-viral gene delivery
systems based on polyplexes of nucleic acids with various cationic polymers. Natural …

The objective of this study was to investigate the transfection efficiency of quaternized N-(4-
N, N-dimethylaminobenzyl) chitosan; TM-Bz-CS, using the plasmid DNA encoding green …

Three novel diamine-modified chitosan derivatives were synthesized from N-maleyl chitosan
via Michael addition reaction with 1, 2-diaminoethane, 1, 4-diaminobutane, and 1, 6 …

A series of N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan chloride (HTCC) samples
with various degrees of quaternization ranging from 12.4 to 43.7% was synthesized. The …

Cationic polymers have the potential for DNA complexation and it is recognised that they
may be useful as non-viral vectors for gene delivery. Highly purified chitosan fractions of< …

To endow the cationic polysaccharides with solubility in the whole pH-range without loss of
functionality of the amino groups, different chitosan samples were treated with …

The selective introduction of a trimethylammonium cationic group into the C-6 position of
chitosan (Cs) was successfully performed by “click chemistry” for the first time, and the 6-N …

In this study, three kinds of methylated chitosan containing different aromatic moieties were
synthesized by two steps, reductive amination and methylation, respectively. The chemical …

Background Chitosan derivatives are potential candidates for gene delivery because they
are biocompatible and low toxic. However, their use has been limited by their moderate …