Wall shear stress–an important determinant of endothelial cell function and structure–in the arterial system in vivo: discrepancies with theory

RS Reneman, T Arts, APG Hoeks - Journal of vascular research, 2006 - karger.com
It has been well established that wall shear stress is an important determinant of endothelial
cell function and gene expression as well as of its structure. There is increasing evidence …

Wall shear stress as measured in vivo: consequences for the design of the arterial system

RS Reneman, APG Hoeks - Medical & biological engineering & computing, 2008 - Springer
Based upon theory, wall shear stress (WSS), an important determinant of endothelial
function and gene expression, has been assumed to be constant along the arterial tree and …

Effects of shear stress on endothelial cells: go with the flow

DA Chistiakov, AN Orekhov, YV Bobryshev - Acta physiologica, 2017 - Wiley Online Library
Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

A noninvasive method to estimate wall shear rate using ultrasound

PJ Brands, APG Hoeks, L Hofstra… - Ultrasound in medicine & …, 1995 - Elsevier
Wall shear stress (blood viscosity× wall shear rate), imposed by the flowing blood, and blood
pressure are the main mechanical forces acting on a blood vessel wall. Accurate …

Wall shear stress: theoretical considerations and methods of measurement

D Katritsis, L Kaiktsis, A Chaniotis, J Pantos… - Progress in …, 2007 - Elsevier
In arterial blood flow, the wall shear stress expresses the force per unit area exerted by the
wall on the fluid in a direction on the local tangent plane. There is substantial evidence that …

Role of hemodynamic shear stress in cardiovascular disease

E Cecchi, C Giglioli, S Valente, C Lazzeri, GF Gensini… - Atherosclerosis, 2011 - Elsevier
Atherosclerosis is the main cause of morbidity and mortality in the Western world.
Inflammation and blood flow alterations are new markers emerging as possible …

Large variations in absolute wall shear stress levels within one species and between species

C Cheng, F Helderman, D Tempel, D Segers, B Hierck… - Atherosclerosis, 2007 - Elsevier
Wall shear stress (WSS), the frictional force between blood and endothelium, is an important
determinant of vascular function. It is generally assumed that WSS remains constant at a …

Haemodynamic wall shear stress, endothelial permeability and atherosclerosis—A triad of controversy

PD Weinberg - Frontiers in Bioengineering and Biotechnology, 2022 - frontiersin.org
A striking feature of atherosclerosis is its patchy distribution within the vascular system;
certain arteries and certain locations within each artery are preferentially affected. Identifying …

Shear stress–initiated signaling and its regulation of endothelial function

J Zhou, YS Li, S Chien - Arteriosclerosis, thrombosis, and vascular …, 2014 - Am Heart Assoc
Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where
blood flow pattern is disturbed rather than being laminar, and wall shear stress has an …

[PDF][PDF] Vascular wall shear stress: basic principles and methods

TG Papaioannou, C Stefanadis - Hellenic J Cardiol, 2005 - hellenicjcardiol.org
Special Article produces not only circumferential but also normal tensions. The direction of
the shear stress vector is determined by the direction of the blood flow velocity vector very …