Large bone defects are a major global health concern. Bone tissue engineering (BTE) is the
most promising alternative to avoid the drawbacks of autograft and allograft bone …

Successfully regenerating damaged or diseased bone and other joint tissues will require a
detailed understanding of how joint specific environmental cues regulate the fate of …

Bone marrow-derived mesenchymal stem and stromal cells (MSCs) are promising
candidates for cell-based therapies in diverse conditions including tissue engineering …

Bone is a load-bearing tissue and physical forces play key roles in the development and
maintenance of its structure. Mechanical cues can stimulate the expression of an osteogenic …

Topography-driven alterations in cell morphology tremendously influence cell biological
processes, particularly stem cell differentiation. Aligned topography is known to alter the cell …

Extracellular matrix (ECM) is comprised of different types of proteins, which change in
composition and ratios during morphogenesis and disease progression. ECM proteins …

Cells are known to perceive their microenvironment through extracellular and intracellular
mechanical signals. Upon sensing mechanical stimuli, cells can initiate various downstream …

Owing to their self‐renewal and differentiation ability, stem cells are conducive for repairing
injured tissues, making them a promising source of seed cells for tissue engineering. The …

Large bone defects are a major health concern worldwide. The conventional bone repair
techniques (eg, bone-grafting and Masquelet techniques) have numerous drawbacks, which …

In bone tissue engineering, the design of in vitro models able to recreate both the chemical
composition, the structural architecture, and the overall mechanical environment of the …