Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

The core of the drug research and screening processes is predicting the effect of drugs prior
to human clinical trials. Due to the 2D cell culture and animal models' poor predictability, the …

Highlights•Physiologically relevant organ models based on microfabrication and
bioengineering.•Recent progress on organ-on-a-chip systems simulating kidney, brain, lung …

The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …

Recent advances in integrating microengineering and tissue engineering have generated
promising microengineered physiological models for experimental medicine and …

Although basic scientific research has generated methodological and technical innovations
rapidly in recent decades, translational science has not kept pace. 1, 2 Among the factors …

The high rate of failure during drug development is well-known, however recent advances in
tissue engineering and microfabrication have contributed to the development of …

Developing biologically relevant models of human tissues and organs is an important
enabling step for disease modeling and drug discovery. Recent advances in tissue …

The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …