Fibroblast growth factor 21 controls mitophagy and muscle mass
LJ Oost, M Kustermann, A Armani… - Journal of cachexia …, 2019 - Wiley Online Library
Background Skeletal muscle is a plastic tissue that adapts to changes in exercise, nutrition,
and stress by secreting myokines and myometabolites. These muscle‐secreted factors have …
and stress by secreting myokines and myometabolites. These muscle‐secreted factors have …
Understanding the physiology of FGF21
FM Fisher, E Maratos-Flier - Annual review of physiology, 2016 - annualreviews.org
Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …
FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling
F Ribas, J Villarroya, E Hondares, M Giralt… - Biochemical …, 2014 - portlandpress.com
Although the liver is generally considered the main site of production of FGF21 (fibroblast
growth factor-21), high FGF21 levels have been found to be associated with neuromuscular …
growth factor-21), high FGF21 levels have been found to be associated with neuromuscular …
[HTML][HTML] Skeletal muscle and bone–emerging targets of fibroblast growth factor-21
H Sun, M Sherrier, H Li - Frontiers in physiology, 2021 - frontiersin.org
Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family, which functions
as a powerful endocrine and paracrine regulator of glucose and lipid metabolism. In addition …
as a powerful endocrine and paracrine regulator of glucose and lipid metabolism. In addition …
[HTML][HTML] Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action
M Ost, V Coleman, A Voigt, EM van Schothorst… - Molecular …, 2016 - Elsevier
Objective Fibroblast growth factor 21 (FGF21) was recently discovered as stress-induced
myokine during mitochondrial disease and proposed as key metabolic mediator of the …
myokine during mitochondrial disease and proposed as key metabolic mediator of the …
Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α …
K Ji, J Zheng, J Lv, J Xu, X Ji, YB Luo, W Li… - Free Radical Biology …, 2015 - Elsevier
Abstract Fibroblast growth factor 21 (FGF21) is a growth factor with pleiotropic effects on
regulating lipid and glucose metabolism. Its expression is increased in skeletal muscle of …
regulating lipid and glucose metabolism. Its expression is increased in skeletal muscle of …
[HTML][HTML] FGF21 as modulator of metabolism in health and disease
C Tezze, V Romanello, M Sandri - Frontiers in physiology, 2019 - frontiersin.org
Fibroblast growth factor 21 (FGF21) is a hormone that regulates important metabolic
pathways. FGF21 is expressed in several metabolically active organs and interacts with …
pathways. FGF21 is expressed in several metabolically active organs and interacts with …
FGF19 protects skeletal muscle against obesity‐induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT‐1/PGC‐α pathway
A Guo, K Li, HC Tian, Z Fan, QN Chen… - Journal of Cellular …, 2021 - Wiley Online Library
Obesity is associated with biological dysfunction in skeletal muscle. As a condition of obesity
accompanied by muscle mass loss and physical dysfunction, sarcopenic obesity (SO) has …
accompanied by muscle mass loss and physical dysfunction, sarcopenic obesity (SO) has …
Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity
FL Mashili, RL Austin, AS Deshmukh… - Diabetes/metabolism …, 2011 - Wiley Online Library
Background Fibroblast growth factor (FGF) 21, a novel member of the FGF family, plays a
role in a variety of endocrine functions, including regulation of glucose and lipid metabolism …
role in a variety of endocrine functions, including regulation of glucose and lipid metabolism …
[HTML][HTML] FGF21 is an Akt-regulated myokine
Y Izumiya, HA Bina, N Ouchi, Y Akasaki… - FEBS letters, 2008 - Elsevier
Fibroblast growth factor-21 (FGF21) functions as a metabolic regulator. The FGF21 transcript
is reported to be abundantly expressed in liver, but little is known about the regulation of …
is reported to be abundantly expressed in liver, but little is known about the regulation of …