Experimental studies of viral gene delivery generally support the principle that virus-
mediated gene transfer is indeed possible. However, the field of gene therapy has not yet …

Over the last three decades, interest in the field of gene therapy seems to have fluctuated
between hot and cold. Encouraging pre-clinical and clinical data has demonstrated the …

Gene therapy includes the application of various viral vectors, which represent most types
and families of viruses, suitable for infection of mammalian host cells. Both hereditary …

The efficient delivery of therapeutic genes and appropriate gene expression are the crucial
issues for clinically relevant gene therapy. Viruses are naturally evolved vehicles which …

In the late 1970s, it was predicted that gene therapy would be applied to humans within a
decade. However, despite some success, gene therapy has still not become a routine …

The huge potential for gene therapy to cure a wide range of diseases has led to high
expectations and a great increase in research efforts in this area. The first human gene …

Within the past decade, gene therapy strategies have come to the forefront of novel
therapeutics. Tremendous advances in vector technology along with deeper understandings …

Problems related to the safety and efficacy of gene therapies have checked the enthusiasm
once surrounding this field, though it remains a promising approach for the treatment of …

Although most research in the field of somatic gene therapy has investigated the use of
recombinant viruses for transferring genes into somatic target cells, various methods for …

Gene therapy is now being applied to the treatment of a wide variety of acquired and
inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency …