SARS-CoV-2 variants acquire mutations in spike that promote immune evasion and impact
other properties that contribute to viral fitness such as ACE2 receptor binding and cell entry …

Early in the current pandemic, the D614G mutation arose in the Spike protein of SARS-CoV-
2 and quickly became the dominant variant globally. Mounting evidence suggests D614G …

Substitutions that fix between SARS-CoV-2 variants can transform the mutational landscape
of future evolution via epistasis. For example, large epistatic shifts in mutational effects …

The continual evolution of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-
2) and the emergence of variants that show resistance to vaccines and neutralizing …

The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance
to vaccines and neutralizing antibodies threaten to prolong the COVID-19 pandemic …

New variants of SARS-CoV-2 are continually emerging with mutations in spike associated
with increased transmissibility and immune escape. Phenotypic maps can inform the …

A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19
pandemic. However, the mutational impact on viral spread and vaccine efficacy remains to …

Understanding SARS-CoV-2 evolution and host immunity is critical to control COVID-19
pandemics. At the core is an arms-race between SARS-CoV-2 antibody and angiotensin …

The Omicron BA. 1 variant emerged in late 2021 and quickly spread across the world.
Compared to the earlier SARS-CoV-2 variants, BA. 1 has many mutations, some of which …

Deep mutational scanning (DMS) is a high-throughput experimental technique that
measures the effects of thousands of mutations to a protein. These experiments can be …