Increased prostaglandin E2 (PGE2) synthesis involves multiple enzymes and two isoforms
of the terminal enzyme of this biosynthetic pathway, PGE synthase (PGES), were recently …

Increased prostaglandin (PG) synthesis by fetal membranes occurs at parturition. PGE2
synthesis from arachidonic acid involves multiple enzymes and two isoforms of the terminal …

Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived
prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties …

Initiation and maintenance of labor in humans is associated with an increase in
prostaglandin synthesis by intrauterine tissues. The objective of the present study was to …

We have evaluated the effect of chorioamnionitis on the protein expression of microsomal
and cytosolic prostaglandin E2 synthases (mPGES and cPGES) in preterm human …

Since the controversies regarding the use of non-steroidal anti-inflammatory drugs (NSAIDs)
and selective cyclo-oxygenase (COX)-2 antagonists for the treatment of preterm labour …

We have documented the presence of PGHS-1 and PGHS-2 in human chorion and decidua
throughout gestation and with term and preterm labor. We have demonstrated that the …

Prostaglandins play an important role in reproduction, particularly in pregnancy and
parturition. We investigated the expression of prostaglandin endoperoxide H synthase …

Prostaglandin E 2 (PGE 2) production involves the activity of a multistep biosynthetic
pathway. The terminal components of this cascade, two PGE 2 synthases (PGES), have very …

We previously showed that cytosolic prostaglandin (PG) E synthase (cPGES/p23) which
isomerizes PGH2 to PGE2, is essential for fetal mouse development. Embryonic fibroblasts …