Recent developments in applied developmental physiology have provided well-defined
methodologies for producing human stem cell derived cardiomyocytes. The cardiomyocytes …

The ability of human pluripotent stem cells to form all cells of the body has provided many
opportunities to study disease and produce cells that can be used for therapy in …

The human heart is the first organ to develop during embryogenesis and is arguably the
most essential organ for life. However, after birth, the heart has very little capacity to repair …

Human induced pluripotent stem cells (hiPSCs) can be used to generate various cell types
in the human body. Hence, hiPSC-derived cardiomyocytes (hiPSC-CMs) represent a …

The pressing need for effective cell therapy for the heart has led to the investigation of
suitable cell sources for tissue replacement. In recent years, human pluripotent stem cell …

Heart attack remains the leading cause of death in both men and women worldwide. Stem
cell-based therapies, including the use of engineered cardiac tissues, have the potential to …

In vitro surrogate models of human cardiac tissue hold great promise in disease modeling,
cardiotoxicity testing, and future applications in regenerative medicine. However, the …

Recent advances in pluripotent stem cell research have provided investigators with potent
sources of cardiogenic cells. However, tissue engineering methodologies to assemble …

Engineered heart tissue has emerged as a personalized platform for drug screening. With
the advent of induced pluripotent stem cell (iPSC) technology, patient-specific stem cells can …

Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …