Botulinum neurotoxins are metalloproteases that specifically cleave N-ethylmaleimide-
sensitive factor attachment protein receptor (SNARE) proteins in synaptic terminals, resulting …

In recent years, numerous studies have highlighted the significant use of botulinum
neurotoxins (BoNTs) in the human therapy of various motor and autonomic disorders. The …

Botulinum neurotoxins (BoNTs), proteases specific for the SNARE proteins, are used to
study the molecular machinery supporting exocytosis and are used to treat human diseases …

Botulinum neurotoxin (BoNT), the causative agent of botulism, is acknowledged to be the
most poisonous protein known. BoNT proteases disable synaptic vesicle exocytosis by …

Botulinum toxins are metalloproteases that act inside nerve terminals and block
neurotransmitter release via their activity directed specifically on SNARE proteins. This …

Botulinum neurotoxins produced by various Clostridium sp are the most potent acute lethal
toxins known, and yet they have found increasing use in the clinical treatment of diseases or …

Botulinum neurotoxin serotype A (BoNT/A) has achieved a dichotomous status in modern
medicine; it is both a versatile treatment for several neurological disorders and a lethal …

Botulinum toxins are metalloproteases that act inside nerve terminals and block
neurotransmitter release through their cleavage of components of the exocytosis machinery …

The clostridial neurotoxins (CNTs) are among the most potent protein toxins known to
humans. CNTs include seven serotypes (A~ G) of botulinum toxins (BoNTs), which cause …

Botulinum neurotoxins (BoNTs) are potent inhibitors of synaptic vesicle fusion and
transmitter release. The natural target of BoNTs is the peripheral neuromuscular junction …