Drug-induced hepatotoxicity (DIH) represents the main cause of drug withdrawal from
therapy. Despite their numerous benefits, oral contraceptives (OCs) present several adverse …

Estrogens are the most commonly used as oral contraceptives (OCs) to control birth and as
hormonal replacement therapy (HRT) by millions of women all over the world. In men, they …

Oxidative stress plays a major part in the pathogenesis of drug-induced liver injury. Yet,
overcoming it with other xenobiotics impose additional risks. In this study, we consider the …

Alcohol is a potent hepatotoxin and that Alcoholic Liver Disease (ALD) is a major disorder of
the liver resulting from alcoholic oxidative stress. So the purpose of the study was to …

Ethinyl oestradiol (EO) is the most commonly used as a component of oral contraceptive and
hormonal replacement therapy (HRT) in women. However, its excessive and prolonged use …

Estrogens are effective antioxidants in diverse biological systems. Despite their antioxidant
activities, it is not known yet whether estrogens prevent or alleviate liver toxicity induced by …

Vitamin E (α-Tocopherol [α-Toc]) is the primary membrane bound, lipid-soluble, chain-
breaking antioxidant that has been reported to protect against lipid peroxidation-induced …

Vitamin E (α-tocopherol) has demonstrated antioxidant activity and gene-regulatory
properties. d-Galactosamine (D-GalN)-induced cell death is mediated by nitric oxide in …

17α-Ethinylestradiol (17-EE) is used in formulations of contraceptives and hormone
replacement therapy because it is an estradiol derivative. However, it has been associated …

Acute liver damage caused by acetaminophen overdose is a significant clinical problem and
could benefit from new therapeutic strategies. Objective. This study investigated the …