Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: composition, structure and barrier properties
BC Huck, X Murgia, S Frisch, M Hittinger… - Advanced Drug Delivery …, 2022 - Elsevier
Mucus covers all wet epithelia and acts as a protective barrier. In the airways of the lungs,
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …
Modelling the bronchial barrier in pulmonary drug delivery: a human bronchial epithelial cell line supplemented with human tracheal mucus
X Murgia, H Yasar, C Carvalho-Wodarz, B Loretz… - European Journal of …, 2017 - Elsevier
The airway epithelium together with the mucus layer coating it forms a protective system that
efficiently filters and removes potentially harmful particles contained in inhaled air. The same …
efficiently filters and removes potentially harmful particles contained in inhaled air. The same …
Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers
Airway mucus is a complex viscoelastic gel that provides a defensive physical barrier and
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …
[HTML][HTML] In vitro investigation on the impact of airway mucus on drug dissolution and absorption at the air-epithelium interface in the lungs
E Cingolani, S Alqahtani, RC Sadler, D Prime… - European Journal of …, 2019 - Elsevier
Although the mucus layer is the first biological barrier encountered by inhaled drugs upon
their deposition in the upper airways, its potential impact on drug dissolution and absorption …
their deposition in the upper airways, its potential impact on drug dissolution and absorption …
Mucociliary transport and cough in humans
WM Foster - Pulmonary pharmacology & therapeutics, 2002 - Elsevier
The mucus lining of the respiratory tract originates from products of secretory cells
interspersed among mucosal cells or within submucosal glands and protects the underlying …
interspersed among mucosal cells or within submucosal glands and protects the underlying …
Modeling airway dysfunction in asthma using synthetic mucus biomaterials
As asthma worsens, occlusion of airways with mucus significantly contributes to airflow
obstruction and reduced lung function. Recent evidence from clinical studies has shown …
obstruction and reduced lung function. Recent evidence from clinical studies has shown …
Role of the physiochemical properties of mucus in the protection of the respiratory epithelium
S Girod, JM Zahm, C Plotkowski… - European Respiratory …, 1992 - Eur Respiratory Soc
The respiratory mucus is a very complex biological material, which possesses both flow and
deformation rheological properties, characterized by non-linear and time-dependent …
deformation rheological properties, characterized by non-linear and time-dependent …
Mucus, microbiomes and pulmonary disease
OW Meldrum, SH Chotirmall - Biomedicines, 2021 - mdpi.com
The respiratory tract harbors a stable and diverse microbial population within an
extracellular mucus layer. Mucus provides a formidable defense against infection and …
extracellular mucus layer. Mucus provides a formidable defense against infection and …
Mucin biopolymers and their barrier function at airway surfaces
In the lung, the airway epithelium produces secreted and tethered mucin biopolymers to
form a mucus hydrogel layer and a surface-attached polymer brush layer. These layers work …
form a mucus hydrogel layer and a surface-attached polymer brush layer. These layers work …
A new paradigm in respiratory hygiene: increasing the cohesivity of airway secretions to improve cough interaction and reduce aerosol dispersion
G Zayas, J Dimitry, A Zayas, D O'Brien, M King - BMC Pulmonary Medicine, 2005 - Springer
Background Infectious respiratory diseases are transmitted to non-infected subjects when an
infected person expels pathogenic microorganisms to the surrounding environment when …
infected person expels pathogenic microorganisms to the surrounding environment when …