Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: composition, structure and barrier properties

BC Huck, X Murgia, S Frisch, M Hittinger… - Advanced Drug Delivery …, 2022 - Elsevier
Mucus covers all wet epithelia and acts as a protective barrier. In the airways of the lungs,
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …

Modelling the bronchial barrier in pulmonary drug delivery: a human bronchial epithelial cell line supplemented with human tracheal mucus

X Murgia, H Yasar, C Carvalho-Wodarz, B Loretz… - European Journal of …, 2017 - Elsevier
The airway epithelium together with the mucus layer coating it forms a protective system that
efficiently filters and removes potentially harmful particles contained in inhaled air. The same …

Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers

R Pangeni, T Meng, S Poudel, D Sharma… - International Journal of …, 2023 - Elsevier
Airway mucus is a complex viscoelastic gel that provides a defensive physical barrier and
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …

[HTML][HTML] In vitro investigation on the impact of airway mucus on drug dissolution and absorption at the air-epithelium interface in the lungs

E Cingolani, S Alqahtani, RC Sadler, D Prime… - European Journal of …, 2019 - Elsevier
Although the mucus layer is the first biological barrier encountered by inhaled drugs upon
their deposition in the upper airways, its potential impact on drug dissolution and absorption …

Mucociliary transport and cough in humans

WM Foster - Pulmonary pharmacology & therapeutics, 2002 - Elsevier
The mucus lining of the respiratory tract originates from products of secretory cells
interspersed among mucosal cells or within submucosal glands and protects the underlying …

Modeling airway dysfunction in asthma using synthetic mucus biomaterials

D Song, E Iverson, L Kaler, S Bader… - ACS biomaterials …, 2021 - ACS Publications
As asthma worsens, occlusion of airways with mucus significantly contributes to airflow
obstruction and reduced lung function. Recent evidence from clinical studies has shown …

Role of the physiochemical properties of mucus in the protection of the respiratory epithelium

S Girod, JM Zahm, C Plotkowski… - European Respiratory …, 1992 - Eur Respiratory Soc
The respiratory mucus is a very complex biological material, which possesses both flow and
deformation rheological properties, characterized by non-linear and time-dependent …

Mucus, microbiomes and pulmonary disease

OW Meldrum, SH Chotirmall - Biomedicines, 2021 - mdpi.com
The respiratory tract harbors a stable and diverse microbial population within an
extracellular mucus layer. Mucus provides a formidable defense against infection and …

Mucin biopolymers and their barrier function at airway surfaces

D Song, D Cahn, GA Duncan - Langmuir, 2020 - ACS Publications
In the lung, the airway epithelium produces secreted and tethered mucin biopolymers to
form a mucus hydrogel layer and a surface-attached polymer brush layer. These layers work …

A new paradigm in respiratory hygiene: increasing the cohesivity of airway secretions to improve cough interaction and reduce aerosol dispersion

G Zayas, J Dimitry, A Zayas, D O'Brien, M King - BMC Pulmonary Medicine, 2005 - Springer
Background Infectious respiratory diseases are transmitted to non-infected subjects when an
infected person expels pathogenic microorganisms to the surrounding environment when …