[HTML][HTML] Shared and distinct transcriptomic cell types across neocortical areas

B Tasic, Z Yao, LT Graybuck, KA Smith, TN Nguyen… - Nature, 2018 - nature.com
The neocortex contains a multitude of cell types that are segregated into layers and
functionally distinct areas. To investigate the diversity of cell types across the mouse …

[HTML][HTML] Single-cell delineation of lineage and genetic identity in the mouse brain

RC Bandler, I Vitali, RN Delgado, MC Ho… - Nature, 2022 - nature.com
During neurogenesis, mitotic progenitor cells lining the ventricles of the embryonic mouse
brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic …

Conserved cell types with divergent features in human versus mouse cortex

RD Hodge, TE Bakken, JA Miller, KA Smith, ER Barkan… - Nature, 2019 - nature.com
Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA …

[HTML][HTML] Phenotypic variation of transcriptomic cell types in mouse motor cortex

F Scala, D Kobak, M Bernabucci, Y Bernaerts… - Nature, 2021 - nature.com
Cortical neurons exhibit extreme diversity in gene expression as well as in morphological
and electrophysiological properties 1, 2. Most existing neural taxonomies are based on …

Human neocortical expansion involves glutamatergic neuron diversification

J Berg, SA Sorensen, JT Ting, JA Miller, T Chartrand… - Nature, 2021 - nature.com
The neocortex is disproportionately expanded in human compared with mouse,, both in its
total volume relative to subcortical structures and in the proportion occupied by …

Individual human cortical progenitors can produce excitatory and inhibitory neurons

RN Delgado, DE Allen, MG Keefe, WR Mancia Leon… - Nature, 2022 - nature.com
The cerebral cortex is a cellularly complex structure comprising a rich diversity of neuronal
and glial cell types. Cortical neurons can be broadly categorized into two classes …

[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

Z Yao, CTJ van Velthoven, M Kunst, M Zhang… - Nature, 2023 - nature.com
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …

A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex

Z Yao, H Liu, F Xie, S Fischer, RS Adkins, AI Aldridge… - Nature, 2021 - nature.com
Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased
samples of the diverse cell types in the brain,–. With the proliferation of multi-omics datasets …

Molecular logic of cellular diversification in the mouse cerebral cortex

DJ Di Bella, E Habibi, RR Stickels, G Scalia, J Brown… - Nature, 2021 - nature.com
The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …

Epigenomic diversity of cortical projection neurons in the mouse brain

Z Zhang, J Zhou, P Tan, Y Pang, AC Rivkin… - Nature, 2021 - nature.com
Neuronal cell types are classically defined by their molecular properties, anatomy and
functions. Although recent advances in single-cell genomics have led to high-resolution …