We have isolated a novel otx-like homeobox gene, Crx, from the mouse retina. Crx
expression is restricted to developing and mature photoreceptor cells. CRX bound and …

The otd/Otx gene family encodes paired-like homeodomain proteins that are involved in the
regulation of anterior head structure and sensory organ development. Using the yeast one …

purpose. It remains unclear which gene induction effectively generates photoreceptor-
specific phenotypes from nonretinal tissues. The purpose of this study was to determine …

Background: Terminal differentiation of many cell types is controlled and maintained by
tissue or cell-specific transcription factors. Little is known, however, of the transcriptional …

Photoreceptors provide an excellent model for studies of vertebrate neuronal differentiation,
and many human diseases resulting in blindness primarily affect photoreceptors. There is …

Otx family homeoproteins Otx2 and Crx are expressed in photoreceptor precursor cells and
bind to the common DNA-binding consensus sequence, but these two proteins have distinct …

purpose. To isolate and characterize a zebrafish Crx homologue. Mammalian Crx genes are
expressed specifically in photoreceptors and pinealocytes, regulate photoreceptor gene …

RX, a homeodomain-containing protein essential for proper eye development (Mathers, PH
Grinberg, A., Mahon, KA, and Jamrich, M.(1997) Nature 387, 603–607), binds to the …

Crx, an Otx-like homeobox gene, is expressed primarily in the photoreceptors of the retina
and in the pinealocytes of the pineal gland. The CRX homeodomain protein is a …

Development of the vertebrate eye has been found to require the activity of several genes
encoding homeodomain proteins (Freund, C., Horsford, DJ & McInnes, RR (1996) Hum. Mol …