Sixteen different types of lipid-conjugated siRNAs containing saturated and unsaturated fatty acids and exhibiting enhanced RNAi potency
T Kubo, Y Nishimura, Y Sato, K Yanagihara… - ACS chemical …, 2020 - ACS Publications
SiRNAs are strong gene-silencing agents that function in a target sequence-specific
manner. Although siRNAs might one day be used in therapy for intractable diseases such as …
manner. Although siRNAs might one day be used in therapy for intractable diseases such as …
Preparation of Lipid-Conjugated SiRNA Oligonucleotides for Enhanced Gene Inhibition in Mammalian Cells
S Grijalvo, SM Ocampo, JC Perales, R Eritja - Design and Delivery of …, 2021 - Springer
Nucleic acid conjugates are promising drugs for treating gene-related diseases.
Conjugating specific units like lipids, cell-penetrating peptides, polymers, antibodies, and …
Conjugating specific units like lipids, cell-penetrating peptides, polymers, antibodies, and …
The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo
Lipid-conjugated small-interfering RNAs (siRNAs) exhibit accumulation and gene silencing
in extrahepatic tissues, providing an opportunity to expand therapeutic siRNA utility beyond …
in extrahepatic tissues, providing an opportunity to expand therapeutic siRNA utility beyond …
Multifunctional pH-sensitive amino lipids for siRNA delivery
RNA interference (RNAi) represents a powerful modality for human disease therapy that can
regulate gene expression signature using small interfering RNA (siRNA). Successful …
regulate gene expression signature using small interfering RNA (siRNA). Successful …
Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo
Small interfering RNA (siRNA)-based therapies are proving to be efficient for treating liver-
associated disorders. However, extra-hepatic delivery remains challenging, limiting …
associated disorders. However, extra-hepatic delivery remains challenging, limiting …
Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery
KP Mahon, KT Love, KA Whitehead, J Qin… - Bioconjugate …, 2010 - ACS Publications
The application of RNA interference (RNAi), either in the clinic or in the laboratory, requires
safe and effective delivery methods. Here, we develop a combinatorial approach to …
safe and effective delivery methods. Here, we develop a combinatorial approach to …
Gene-silencing potency of symmetric and asymmetric lipid-conjugated siRNAs and its correlation with dicer recognition
T Kubo, K Yanagihara, Y Sato, Y Nishimura… - Bioconjugate …, 2013 - ACS Publications
Three types of siRNAs and three types of left-overhang siRNAs (LoRNAs) were synthesized
along with their conjugations with palmitic acid (C16) to investigate the correlation between …
along with their conjugations with palmitic acid (C16) to investigate the correlation between …
Effective carrier-free gene-silencing activity of sphingosine-modified siRNAs
C Fernandez, I Giorgees, E Goss… - Organic & Biomolecular …, 2023 - pubs.rsc.org
RNA interference (RNAi) is a natural cellular process that silences the expression of target
genes in a sequence-specific way by mediating targeted mRNA degradation. One of the …
genes in a sequence-specific way by mediating targeted mRNA degradation. One of the …
[HTML][HTML] Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo
Lipid conjugation supports delivery of small interfering RNAs (siRNAs) to extrahepatic
tissues, expanding the therapeutic potential of siRNAs beyond liver indications. However …
tissues, expanding the therapeutic potential of siRNAs beyond liver indications. However …
Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group
NS Petrova, IV Chernikov… - Nucleic acids …, 2012 - academic.oup.com
The conjugation of siRNA to molecules, which can be internalized into the cell via natural
transport mechanisms, can result in the enhancement of siRNA cellular uptake. Herein, the …
transport mechanisms, can result in the enhancement of siRNA cellular uptake. Herein, the …