Modern strategies in drug development employ in silico techniques in the design of
compounds as well as estimations of pharmacokinetics, pharmacodynamics and toxicity …

The portfolio of compounds approved for inhalation therapy has expanded rapidly for
treatment of lung diseases. To assess the efficacy and safety of inhaled medicines, a better …

During the process of inhalable formulation development a deep knowledge of the
physicochemical characteristics of the drug and formulation components and the biological …

In order to answer the question “what research remains to be done?” we review the current
state of the art in pharmaceutical aerosol deposition modeling and explore possible in vivo …

Prediction of local exposure following inhalation of a locally acting pulmonary drug is central
to the successful development of novel inhaled medicines, as well as generic equivalents …

High-fidelity simulations of the complete airway tree are still largely beyond current
computational capabilities. Towards large-scale simulations of the human lung, the current …

This review article is intended to serve as an overview of the current status of the
computational tools and approaches available for predicting respiratory-tract dosimetry of …

Introduction: Pulmonary drug delivery is a complex field of research combining physics
which drive aerosol transport and deposition and biology which underpins efficacy and …

To accurately assess the potential therapeutic effects of airborne drugs, the deposition sites
of inhaled particles must be known. Herein, an original theory is presented for …

Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …