Human aging is characterized by both physical and physiological frailty. A key feature of
frailty, sarcopenia is the age-associated decline in skeletal muscle mass, strength, and …

The age of an individual is an important, independent risk factor for many of the most
common diseases afflicting modern societies. Interleukin‐7 (IL‐7) plays a central, critical role …

The innate immune system is composed of a network of cells including neutrophils, NK and
NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions …

Increased mortality and overexpression of interleukin-6 (IL-6) during inflammatory stress are
well-documented age-associated phenomena; however, the site of IL-6 overexpression is …

Aging is the greatest risk factor for nearly all major chronic diseases, including
cardiovascular diseases, cancer, Alzheimer's and other neurodegenerative diseases of …

Interleukin-6 (IL-6) is a proinflammatory cytokine that is normally tightly regulated and
expressed at low levels, except during infection, trauma, or other stress. Among several …

Interleukin-15 (IL-15) is a skeletal muscle-derived cytokine with favorable effects on muscle
mass and body composition. Modulation of IL-15 levels has been suggested as a treatment …

Inflammation is a physiological process that repairs tissues in response to endogenous or
exogenous aggressions. Nevertheless, a chronic state of inflammation may have detrimental …

Ageing is a global burden. Increasing age is associated with increased incidence of
infections and cancer and decreased vaccine efficacy. This increased morbidity observed …

Cardiovascular dysfunction is a primary independent predictor of age-related morbidity and
mortality. Frailty is associated with activation of inflammatory pathways and fatigue that …