Constitutively erythromycin-resistant apathogens are more difficult to address than inducibly
resistant and efflux-resistant strains. Three series of the 4th generation 2-fluoro 9-oxime …

In the search for new antibiotics active against macrolide-resistant pneumococci and
Haemophilus influenzae, we synthesized a new class of 3-oxo-6-O-methylerythromycin …

Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections;
however, the increasing prevalence of macrolide-resistant pathogens is a public health …

Resistance to telithromycin and off-target effects associated with the metabolic instability
present serious and challenging problems for the development of novel macrolides. Herein …

Four macrolides—6-O-methyl-8a-aza-8a-homoerythromycin, clarithromycin, azithromycin
and azithromycin 11, 12-cyclic carbonate, have been selected for the construction of a series …

In general, potent non-ketolide versions of erythromycin possessed conformationally
constricted two-or three-atom-length sidechains at 3-OH. Novel 14-membered non-ketolides …

A new azithromycin-based series of antibacterial macrolones is reported, which features the
use of a 4 ″-ester linked glycin for tethering the quinolone side chain to the macrolide …

The new class of antibiotics called ketolides is endowed with remarkable antibacterial
activity against macrolide-resistant strains. Further modifications of the 3 keto-macrolactone …

Design Rationale. Structural modification of existing antibiotics remains one of the most
effective approaches for overcoming bacterial resistance. 10 We focused our efforts on the …

Erythromycin was long viewed as a bacteriostatic agent. The erythromycin derivatives, 9-
oxime ketolides have a species-specific bactericidal profile. Among them, the 3′-allyl …