[HTML][HTML] Organotypic cultures as aging associated disease models
MM Sanchez, IA Bagdasarian, W Darch… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Aging remains a primary risk factor for a host of diseases, including leading causes of death.
Aging and associated diseases are inherently multifactorial, with numerous contributing …
Aging and associated diseases are inherently multifactorial, with numerous contributing …
[HTML][HTML] Tissue engineering to better understand senescence: organotypics come of age
DA Milligan, EJ Tyler, CL Bishop - Mechanisms of Ageing and Development, 2020 - Elsevier
The recent advent of 'organs in a dish'has revolutionised the research landscape. These 3D
culture systems have paved the way for translational, post genomics research by enabling …
culture systems have paved the way for translational, post genomics research by enabling …
Animal models of aging research: implications for human aging and age-related diseases
SJ Mitchell, M Scheibye-Knudsen… - Annu. Rev. Anim …, 2015 - annualreviews.org
Aging is characterized by an increasing morbidity and functional decline that eventually
results in the death of an organism. Aging is the largest risk factor for numerous human …
results in the death of an organism. Aging is the largest risk factor for numerous human …
Evaluating health span in preclinical models of aging and disease: guidelines, challenges, and opportunities for geroscience
DM Huffman, JN Justice, MB Stout… - … Series A: Biomedical …, 2016 - academic.oup.com
Life extension is no longer considered sufficient evidence of delayed aging in research
animals. It must also be demonstrated that a broad swathe of health indicators have been …
animals. It must also be demonstrated that a broad swathe of health indicators have been …
Comparison of mice with accelerated aging caused by distinct mechanisms
AU Gurkar, LJ Niedernhofer - Experimental gerontology, 2015 - Elsevier
Aging is the primary risk factor for numerous chronic, debilitating diseases. These diseases
impact quality of life of the elderly and consume a large portion of health care costs. The cost …
impact quality of life of the elderly and consume a large portion of health care costs. The cost …
[HTML][HTML] Opportunities for organoids as new models of aging
JL Hu, ME Todhunter, MA LaBarge… - The Journal of cell …, 2018 - ncbi.nlm.nih.gov
The biology of aging is challenging to study, particularly in humans. As a result, model
organisms are used to approximate the physiological context of aging in humans. However …
organisms are used to approximate the physiological context of aging in humans. However …
Aging preclinical models in oncology field: from cells to aging
W Bouleftour, N Magne - Aging Clinical and Experimental Research, 2022 - Springer
Aging is a universal complex and multifactorial physiological process that leads to the
increasing incidence of various diseases including cancer. Indeed, 40% of individuals aged …
increasing incidence of various diseases including cancer. Indeed, 40% of individuals aged …
Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging
R Weinmüllner, B Zbiral, A Becirovic… - npj Aging and …, 2020 - nature.com
Skin aging is driven by intrinsic and extrinsic factors impacting on skin functionality with
progressive age. One factor of this multifaceted process is cellular senescence, as it has …
progressive age. One factor of this multifaceted process is cellular senescence, as it has …
Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro
L Costello, T Dicolandrea, R Tasseff, R Isfort… - Aging …, 2022 - Wiley Online Library
Human skin ageing is a complex and heterogeneous process, which is influenced by
genetically determined intrinsic factors and accelerated by cumulative exposure to extrinsic …
genetically determined intrinsic factors and accelerated by cumulative exposure to extrinsic …
[HTML][HTML] Cellular models of aging
P Ludovico, HD Osiewacz, V Costa… - Oxidative medicine and …, 2012 - ncbi.nlm.nih.gov
Biological aging is a complex and multifactorial process driven by genetic, environmental,
and stochastic factors that lead to the physiological decline of biological systems. In humans …
and stochastic factors that lead to the physiological decline of biological systems. In humans …