JTE-607 is a small molecule that was developed as an inflammatory cytokine inhibitor and
also as an anti-leukemia reagent for monocytic leukemia. However, the mode of action of …

Alternative polyadenylation (APA) is a widespread mechanism of gene regulation that
generates mRNA isoforms with alternative 3'untranslated regions (3'UTRs). Our previous …

Abstract MCP-1-induced protein-1 (MCPIP1) is a newly identified protein that is crucial to
immune regulation. Mice lacking MCPIP1 gene suffer from severe immune disorders, and …

A novel gene ZC3H12A, encoding MCP‐1‐induced protein 1 (MCPIP), was recently
identified in human peripheral blood monocytes treated with monocyte chemotactic protein 1 …

(Cancer Sci 2010; 101: 774–781) Proinflammatory cytokines and growth factors have been
thought to play crucial roles in the pathology of acute myelogenous leukemia (AML) by …

Asparaginyl-tRNA synthetase (NRS) is not only essential in protein translation but also
associated with autoimmune diseases. Particularly, patients with antibodies that recognize …

This work aimed to investigate the role of long non-coding RNA (lncRNA) PCSK6-AS1 in
inflammatory bowel disease (IBD). The levels of PCSK6-AS1 in human samples were …

Abstract Tumour Necrosis Factor (TNF) potently induces a transient inflammatory response
that must be downregulated once any invasive stimulus has resolved. Yet, how TNF …

The neuroinflammation associated with multiple sclerosis involves activation of astrocytes
that secrete and respond to inflammatory mediators such as IL-1. IL-1 stimulates expression …

It has been reported that IFN‐λs inhibit HCV replication in vitro. But the mechanisms of how
IL‐28A conducts antiviral activity and the functions of IL‐28A‐induced ISGs (IFN‐stimulated …