The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans
The environmental pathogen Cryptococcus neoformans claims over 180,000 lives each
year. Survival of this basidiomycete at host CO 2 concentrations has only recently been …
year. Survival of this basidiomycete at host CO 2 concentrations has only recently been …
Cdk8 and Ssn801 Regulate oxidative stress resistance and virulence in Cryptococcus neoformans
AL Chang, Y Kang, TL Doering - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this
environmental yeast proliferates either extracellularly or within host macrophages. Under …
environmental yeast proliferates either extracellularly or within host macrophages. Under …
[HTML][HTML] Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming
ALM Bloom, RM Jin, J Leipheimer, JE Bard… - Nature …, 2019 - nature.com
A common feature shared by systemic fungal pathogens of environmental origin, such as
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …
[HTML][HTML] The Crz1/Sp1 Transcription Factor of Cryptococcus neoformans Is Activated by Calcineurin and Regulates Cell Wall Integrity
S Lev, D Desmarini, M Chayakulkeeree, TC Sorrell… - PloS one, 2012 - journals.plos.org
Cryptococcus neoformans survives host temperature and regulates cell wall integrity via a
calcium-dependent phosphatase, calcineurin. However, downstream effectors of C …
calcium-dependent phosphatase, calcineurin. However, downstream effectors of C …
A PAS protein directs metabolic reprogramming during cryptococcal adaptation to hypoxia
Y Zhao, X Lin - Mbio, 2021 - Am Soc Microbiol
To aerobic organisms, low oxygen tension (hypoxia) presents a physiological challenge. To
cope with such a challenge, metabolic pathways such as those used in energy production …
cope with such a challenge, metabolic pathways such as those used in energy production …
Genetic contribution to high temperature tolerance in Cryptococcus neoformans
PR Stempinski, JM Zielinski, NH Dbouk, ES Huey… - Genetics, 2021 - academic.oup.com
The human fungal pathogen Cryptococcus neoformans relies on a complex signaling
network for the adaptation and survival at the host temperature. Protein phosphatase …
network for the adaptation and survival at the host temperature. Protein phosphatase …
Unraveling caspofungin resistance in cryptococcus neoformans
N Papon, GH Goldman - MBio, 2021 - Am Soc Microbiol
Cryptococcus neoformans is a basidiomycetous yeast responsible for hundreds of
thousands of deaths a year and is particularly threatening in immunocompromised patients …
thousands of deaths a year and is particularly threatening in immunocompromised patients …
[HTML][HTML] Molecular Mechanisms of Hypoxic Responses via Unique Roles of Ras1, Cdc24 and Ptp3 in a Human Fungal Pathogen Cryptococcus neoformans
YC Chang, A Khanal Lamichhane, HM Garraffo… - PLoS …, 2014 - journals.plos.org
Cryptococcus neoformans encounters a low oxygen environment when it enters the human
host. Here, we show that the conserved Ras1 (a small GTPase) and Cdc24 (the guanine …
host. Here, we show that the conserved Ras1 (a small GTPase) and Cdc24 (the guanine …
Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence
The opportunistic human fungal pathogen Cryptococcus neoformans has tremendous
impact on global health, causing 181,000 deaths annually. Current treatment options are …
impact on global health, causing 181,000 deaths annually. Current treatment options are …
[HTML][HTML] Molecular Dissection of Crz1 and Its Dynamic Subcellular Localization in Cryptococcus neoformans
BJ Chadwick, BE Ross, X Lin - Journal of Fungi, 2023 - mdpi.com
Across lower eukaryotes, the transcription factor Crz1 is dephosphorylated by calcineurin,
which facilitates Crz1 translocation to the nucleus to regulate gene expression. In the fungal …
which facilitates Crz1 translocation to the nucleus to regulate gene expression. In the fungal …
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