Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies

J Ambati, BK Ambati, SH Yoo, S Ianchulev… - Survey of …, 2003 - Elsevier
Age-related macular degeneration is the principal cause of registered legal blindness
among those aged over 65 in the United States, western Europe, Australia, and Japan …

Keypathophysiologic pathways in age-related macular disease

F Roth, A Bindewald, FG Holz - Graefe's Archive for Clinical and …, 2004 - Springer
Purpose To review current knowledge of key pathogenetic pathways in age-related macular
disease (AMD). Methods Experimental evidence and clinical observations are reviewed …

Aging is not a disease: distinguishing age-related macular degeneration from aging

D Ardeljan, CC Chan - Progress in retinal and eye research, 2013 - Elsevier
Age-related macular degeneration (AMD) is a disease of the outer retina, characterized most
significantly by atrophy of photoreceptors and retinal pigment epithelium accompanied with …

Pathogenesis of lesions in late age-related macular disease

FG Holz, D Pauleikhoff, R Klein, AC Bird - American journal of …, 2004 - Elsevier
PURPOSE: To review the evidence that exists concerning the pathogenesis of lesions in late
age-related macular disease (AMD). DESIGN: Review of the literature. METHODS: A review …

Age-related macular degeneration revisited–piecing the puzzle: the LXIX Edward Jackson memorial lecture

JW Miller - American journal of ophthalmology, 2013 - Elsevier
PURPOSE: To present the current understanding of age-related macular degeneration
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …

[HTML][HTML] Regulation of signaling events involved in the pathophysiology of neovascular AMD

H Wang, ME Hartnett - Molecular vision, 2016 - ncbi.nlm.nih.gov
Neovascular age-related macular degeneration (AMD) is a complex disease in which an
individual's genetic predisposition is affected by aging and environmental stresses, which …

Current knowledge and trends in age-related macular degeneration: genetics, epidemiology, and prevention

R Velez-Montoya, SCN Oliver, JL Olson, SL Fine… - Retina, 2014 - journals.lww.com
Purpose: To address the most dynamic and current issues concerning human genetics, risk
factors, pharmacoeconomics, and prevention regarding age-related macular degeneration …

Mechanisms of age‐related macular degeneration and therapeutic opportunities

M van Lookeren Campagne, J LeCouter… - The Journal of …, 2014 - Wiley Online Library
As the age of the population increases in many nations, age‐related degenerative diseases
pose significant socioeconomic challenges. One of the key degenerative diseases that …

Age-related macular degeneration

RD Jager, WF Mieler, JW Miller - New England Journal of …, 2008 - Mass Medical Soc
Age-related macular degeneration is the leading cause of irreversible blindness in people
50 years of age or older in the developed world. This article reviews the clinical and …

The genetics of age-related macular degeneration: a review of progress to date

S Haddad, CA Chen, SL Santangelo… - Survey of ophthalmology, 2006 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness
among older adults in the USA and throughout the developed world. Etiological research …