Obesity results from an imbalance between energy intake and expenditure, and many
studies have aimed to determine why obese individuals continue to (over) consume food …

Dopamine is a neurotransmitter that plays a crucial role in adaptive behavior. A wealth of
studies suggests obesity-related alterations in the central dopamine system. The most direct …

Obesity is a major public health problem. The increasing number of obese individuals in the
US adds urgency to the efforts to understand the mechanisms underlying pathological …

Alterations in the dopaminergic system have been implicated in both animal and human
obesity. However, to date, a comprehensive model on the nature and functional relevance of …

Obesity has reached epidemic prevalence, and much research has focused on homeostatic
and nonhomeostatic mechanisms underlying overconsumption of food. Mesocorticolimbic …

Both drug addiction and obesity can be defined as disorders in which the saliency value of
one type of reward (drugs and food, respectively) becomes abnormally enhanced relative to …

The neurobiology underlying obesity is not fully understood. The neurotransmitter serotonin
(5-HT) is established as a satiety-generating signal, but its rewarding role in feeding is less …

Over the past years, evidence has accumulated that obesity is intimately linked to the
integrity of the fronto-striatal system of the human brain. However, the nature and causality of …

Obesity is a major public health problem, which occurs in epidemic proportions. Our
understanding of the systems of the brain related to energy balance has increased over the …

Background: Altered brain dopaminergic and serotonergic pathways have been shown in
obese rodents and humans, but it is unknown whether this is related to obesity per se or to …