Studies of diffusion tensor imaging have focused mainly on the role of deep white matter
tract microstructural abnormalities associated with aging and age-related cognitive decline …

Aging is associated with declining cognitive performance as well as structural changes in
brain gray and white matter (WM). The WM deterioration contributes to a disconnection …

Cerebral white matter (WM) undergoes various degenerative changes with normal aging,
including decreases in myelin density and alterations in myelin structure. We acquired …

Aging is associated with significant white matter deterioration and this deterioration is
assumed to be at least partly a consequence of myelin degeneration. The present study …

Disruption of cerebral white matter has been proposed as an explanation for age-related
cognitive declines. However, the role of specific regions in specific cognitive declines …

Age‐related degeneration of brain white matter (WM) has received a great deal of attention,
with recent studies demonstrating that such changes are correlated with cognitive decline …

The ability to perform complex as well as simple cognitive tasks engages a network of brain
regions that is mediated by the white matter fiber bundles connecting them. Different …

Background: Damage to white matter tracts, resulting in “cerebral disconnection,” may
underlie age-related cognitive decline. Methods: Using diffusion tensor MRI (DTI) to …

Subjective cognitive decline (SCD) may be an at-risk stage of Alzheimer's disease (AD)
occurring prior to amnestic mild cognitive impairment (aMCI). To examine white matter (WM) …

We examined age-related changes in the cerebral white matter. Structural magnetic
resonance images (MRIs) and diffusion tensor images (DTIs) were acquired from 69 healthy …