Polysubstance abuse is common among substance-use disorder patients, and nicotine is
one of the most commonly co-used substances. Epidemiological and clinical laboratory …

Rationale and background Tobacco use through cigarette smoking is the leading
preventable cause of death in the developed world. Nicotine, a psychoactive component of …

Tobacco use through cigarette smoking is the leading preventable cause of death in the
developed world. Nicotine, a psychoactive component of tobacco, appears to play a major …

Nicotine, like other drugs when abused, can produce a wide array of behaviours, some of
which collectively propel 'drug-seeking behaviour'. This review focuses on three stimulus …

The primary aim was to evaluate whether nicotine use alters the high or desire for cocaine
among active cocaine users who concurrently smoke cigarettes. Participants answered the …

Alcohol and nicotine kill over half a million Americans every year. Abuse and addiction to
these drugs represent the leading cause of preventable morbidity and mortality in the United …

It is well established that the continued intake of drugs of abuse is reinforcing—that is
repeated consumption increases preference. This has been shown in some studies to …

Background: Alcohol use disorders and tobacco use contribute significant risk to the global
burden of disease, and each are major public health concerns. Together, alcohol and …

Nicotine dependence is a disease of constantly growing importance. This mini-review
describes the effects of nicotine in humans and focuses on the various laboratory animal …

Risk factors that predict vulnerability for nicotine and other drug abuse have been identified
using preclinical models, and there is close agreement with clinical and epidemiological …