Chronic liver injury due to various hepatotoxic stimuli commonly leads to fibrosis, which is a
crucial factor contributing to liver disease-related mortality. Despite the potential benefits of …

Ethnopharmacological relevance Huangqi decoction (HQD) is a well-known traditional
Chinese herbal formulation, It is an effective treatment for consumptive disease and chronic …

Hepatic stellate cells (HSCs) are key mediators of fibrogenesis, and the regulation of their
activation is now viewed as an attractive target for the treatment of liver fibrosis. Here, the …

Background Hepatic fibrosis is considered integral to the progression of chronic liver
diseases, as it leads to the development of cirrhosis and hepatocellular carcinoma. The …

Glaucocalyxin A (GLA) is a biologically active ent-kauranoid diterpenoid isolated from
Rabdosia japonica var. glaucocalyx. A large number of studies have shown that GLA …

METHODS: Male Sprague-Dawley rats underwent common bile duct ligation (BDL) for 14 d
and were treated with Gardenia jasminoides by gavage. The effects of Gardenia …

Our study aimed to explore effects of a characterized ethanol extract of Rosa rugosa (ERS)
on hepatic stellate cells (HSCs) activation and mouse liver fibrosis and their molecular …

Background Hepatic fibrosis, a common pathological feature of chronic liver injuries, is a
serious public health problem and lacks effective therapy. Glycyrrhizic acid (GA) is a …

Kahweol is a diterpene molecule found in Coffea Arabica beans. Previous studies have
shown that coffee reduces liver fibrosis, but it is not clear which component of coffee has the …

Cholestatic liver cirrhosis (CLC) eventually proceeds to end-stage liver failure by mediating
overwhelming deposition of collagen, which is produced by activated interstitial …