Abstract Interleukin 6 (IL6) is an inflammatory cytokine that has been suggested to have an
important role in the pathogenesis of asthma. IL6 single-nucleotide polymorphisms (SNPs) …

IL10 is an anti‐inflammatory cytokine that has been found to have lower production in
macrophages and mononuclear cells from asthmatics. Since reduced IL10 levels may …

Background: Asthma and rhinitis may represent two manifestations of the same airway
disease. Genetic research can increase our understanding of their common or distinct …

Different genes are associated with categorical classifications of asthma severity. However,
continuous outcomes should be used to catch the heterogeneity of asthma phenotypes and …

Background and objective: Polymorphisms in the IL13 gene have been reported to be
associated with susceptibility to asthma. However, a number of studies have shown …

Background. Previously, lots of studies researched the association of interleukin (IL) 13
gene polymorphisms and the risk of asthma, yielding incongruent outcomes. Objective. To …

Background: Interleukin (IL)‐15 is an important mediator in chronic inflammatory diseases.
Recently, we have described the association of IL‐15 haplotypes with bronchial asthma …

BACKGROUND: The IL6R single nucleotide polymorphism (SNP) rs4129267 has recently
been identified as an asthma susceptibility locus in subjects of European ancestry but has …

To cite this article: Beghé B, Hall IP, Parker SG, Moffatt MF, Wardlaw A, Connolly MJ, Fabbri
LM, Ruse C, Sayers I. Polymorphisms in IL13 pathway genes in asthma and chronic …

Asthma and atopy are related conditions that may share similar genetic susceptibility.
Linkage studies have identified a region on chromosome 5q that contains biologic …