The totipotent embryo initiates transcription during zygotic or embryonic genome activation
(EGA, ZGA). ZGA occurs at the 8-cell stage in humans and its failure leads to developmental …

In human embryos, major zygotic genome activation (ZGA) initiates at the eight-cell (8C)
stage. Abnormal ZGA leads to developmental defects and even contributes to the failure of …

The activation of the embryonic genome marks the first major wave of transcription in the
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …

Mammalian development commences with the zygote, which can differentiate into both
embryonic and extraembryonic tissues, a capability known as totipotency. Only the zygote …

Embryonic genome activation (EGA) is a critical step in embryonic development. However,
while EGA has been studied in mice using mouse 2-cell-like cells, human EGA remains …

Currently, two main cell culture models predominate pluripotent stem cell research:
embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Thanks to their …

The cleavage of zygotes generates totipotent blastomeres. In human 8-cell blastomeres,
zygotic genome activation (ZGA) occurs to initiate the ontogenesis program. However …

Embryonic stem cells possess fascinating capacity of self-renewal and developmental
potential, leading to significant progress in understanding the molecular basis of …

Unlike pluripotent cells, which generate only embryonic tissues, totipotent cells can generate
a full organism, including extra-embryonic tissues. A rare population of cells resembling 2 …

Multicellular organisms develop from a single cell, the zygote. This feature is referred to as
totipotency. In the mouse, only the zygote and the 2-cell stage embryo display this attribute …