Flibanserin has preferential affinity for serotonin 5‐HT1A, dopamine D4, and serotonin 5‐
HT2A receptors. In vitro and in microiontophoresis, flibanserin behaves as a 5‐HT1A …

Flibanserin is a 5-HT1A agonist that, in contrast to other 5-HT1A receptor agonists, is
capable of activating 5-HT1A receptors in frontal cortex. Flibanserin also behaves as an …

5‐HT1A receptor agonists have proven to be effective antidepressant medications, however
they suffer from a significant therapeutic lag before depressive symptoms abate. Flibanserin …

Chronic exposure to mild unpredictable stress has previously been found to depress the
consumption of palatable sweet solutions and to block the formation of conditioned place …

The mode of action of antidepressant drugs may be related to mechanisms of receptor
adaptation, involving overall the serotonin 1A (5-HT1A) receptor subtype. However, so far …

Using in vivo intracerebral microdialysis in conscious, freely moving rats, we examined the
effect of flibanserin, a potential antidepressant drug with high affinity for human 5‐HT1A …

Abstract Serotonin (5-HT) reuptake inhibitors (SSRIs) such as fluvoxamine are interesting
compounds. Initially launched as antidepressants, they have been found to be active in …

Preclinical neurochemical studies indicate that buspirone and gepirone bind selectively to
presynaptic (dorsal raphe) and postsynaptic (hippocampus, cortex) 5-hydroxytryptamine 1A …

To clarify the mechanisms of action of blonanserin, an atypical antipsychotic drug, we
studied the effects of systemic administration of blonanserin and risperidone on extracellular …

The present survey compares the effects of antidepressants and their principal metabolites
on reuptake of biogenic amines and on receptor binding. The following antidepressants …