Effect of the anti-androgenic endocrine disruptor vinclozolin on embryonic testis cord formation and postnatal testis development and function

M Uzumcu, H Suzuki, MK Skinner - Reproductive Toxicology, 2004 - Elsevier
Vinclozolin is a systemic dicarboximide fungicide that is used on fruits, vegetables,
ornamental plants, and turf grass. Vinclozolin and its metabolites are known to be endocrine …

Transgenerational effect of the endocrine disruptor vinclozolin on male spermatogenesis

MD Anway, MA Memon, M Uzumcu… - Journal of …, 2006 - Wiley Online Library
The current study was designed to examine the actions of a model endocrine disruptor on
embryonic testis development and male fertility. Pregnant rats (F0) that received a transient …

Characterization of the period of sensitivity of fetal male sexual development to vinclozolin

CJ Wolf, GA LeBlanc, JS Ostby… - Toxicological …, 2000 - academic.oup.com
Vinclozolin is a fungicide whose metabolites are androgen receptor (AR) antagonists.
Previous work in our laboratory showed that perinatal administration of vinclozolin to rats …

Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites

WR Kelce, E Monosson, MP Gamcsik, SC Laws… - Toxicology and applied …, 1994 - Elsevier
Recent studies with vinclozolin, a dicarboximide fungicide, demonstrate that perinatal
exposure to 100 mg vinclozolin/kg/day from Gestational Day 14 through Postnatal Day 3 …

Environmental antiandrogens: low doses of the fungicide vinclozolin alter sexual differentiation of the male rat

J Ostby, E Monosson, WR Kelce… - … and industrial health, 1999 - journals.sagepub.com
In humans and rodents, exposure to antiandrogenic chemicals during sexual differentiation
can produce malformations of the reproductive tract. Perinatal administration of 100 or 200 …

Disruption of sexual function, FSH secretion, and spermiogenesis in rabbits following developmental exposure to vinclozolin, a fungicide

DNR Veeramachaneni, JS Palmer, RP Amann… - …, 2006 - rep.bioscientifica.com
We studied sequelae of prenatal plus infantile exposure of male rabbits to vinclozolin,
because it is ingested by women and children. Female Dutch-Belted rabbits (7–10/group) …

Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis

MD Anway, SS Rekow, MK Skinner - Reproductive toxicology, 2008 - Elsevier
Exposure of gestating female rats to the anti-androgenic endocrine disruptor vinclozolin has
been shown to induce transgenerational adult onset disease phenotypes. The current study …

Vinclozolin—the lack of a transgenerational effect after oral maternal exposure during organogenesis

S Schneider, W Kaufmann, R Buesen… - Reproductive …, 2008 - Elsevier
The purpose of the study was to investigate a possible transgenerational effect of the
fungicide vinclozolin on the male reproductive system following oral exposure since this …

Vinclozolin: a feasibility and sensitivity study of the ILSI-HESI F1-extended one-generation rat reproduction protocol

S Schneider, W Kaufmann, V Strauss… - Regulatory Toxicology …, 2011 - Elsevier
Feasibility of the ILSI-HESI (ACSA) extended one-generation protocol was tested with
vinclozolin (dietary 0, 4, 20, 100mg/kg/day). Parental Wistar rats (n= 25/sex/dose) were …

Peripubertal exposure to the antiandrogenic fungicide, vinclozolin, delays puberty, inhibits the development of androgen-dependent tissues, and alters androgen …

E Monosson, WR Kelce, C Lambright… - Toxicology and …, 1999 - journals.sagepub.com
Vinclozolin is a well-characterized antiandrogenic fungicide. It produces adverse effects
when administered during sexual differentiation, and it alters reproductive function in adult …