BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …

Drug discovery strategies for both pharmaceutical and agrochemical applications are at a
stage of rapid development. More than 30% of sales of drugs for human consumption …

Covering: 2004 to 2006 Natural products have provided considerable value to the
pharmaceutical industry over the past half century. In particular, the therapeutic areas of …

The introduction of high-throughput synthesis and combinatorial chemistry has precipitated
a global decline in the screening of natural products by the pharmaceutical industry. Some …

It seems appropriate to emphasize the topic of natural products at a time when new
compounds are desperately needed to combat the current problems of antibiotic resistance …

Nature has been a source of medicinal agents for thousands of years and continues to be an
abundant source of novel chemotypes and pharmacophores. With only 5 to 15% of the …

This review is an updated and expanded version of the five prior reviews that were
published in this journal in 1997, 2003, 2007, 2012, and 2016. For all approved therapeutic …

Natural products and their derivatives have been and continue to be rich sources for drug
discovery. However, natural products are not drugs. They are produce in nature and through …

The tide toward diminished interest in natural products drug discovery may be turning, for
three reasons: 1. Combinatorial chemistry's promise to fill drug development pipelines with …

This review is an updated and expanded version of two prior reviews that were published in
this journal in 1997 and 2003. In the case of all approved agents the time frame has been …