Melanoma represents one of the most aggressive and drug resistant skin cancers with poor
prognosis in its advanced stages. Despite the increasing number of targeted therapies …

Betulinic acid is a natural product with a range of biological effects, for example potent
antitumor activity. This anticancer property is linked to its ability to induce apoptotic cell …

Betulinic acid (BA), a natural pentacyclic triterpene, was extracted from the white birch tree,
Triphyophyllum peltatum and the jujube tree. In a variety of human cancer cell lines, this …

The mitochondrion plays a crucial role in the process of apoptosis and has thus become one
of the targets for the search for potential chemotherapeutic agents. Betulinic acid [3β …

Betulinic acid (BA), a potential anticancer compound, could induce apoptosis in human
cervical cancer (HeLa) cells, but its mechanism has yet to be fully elucidated. The present …

Ovarian cancer is one of the leading causes of cancer deaths worldwide in women, and the
most malignant cancer among the different gynecological cancers. In this study, we explored …

We previously described that betulinic acid (BetA), a naturally occurring pentacyclic
triterpenoid, induces apoptosis in tumor cells through the mitochondrial pathway. Here, for …

Selective targeting of cancer cells employing multiple combinations as co-drug holds
promise for new generation therapeutics. Betulinic acid (BA), a plant secondary metabolite …

Introduction. Terpenes are the largest known class of organic compounds, widely distributed
in plants. They are grouped considering the number of isoprene units in their structure; …

Background Cell senescence is a process of central importance to the understanding of
aging as well as to the development of new drugs. It is related with genomic instability, which …