Simple Summary For nearly half a century, a mainstay and goal of medical oncology has
been to identify novel anticancer drugs and therapeutic strategies to promote the effective …

Background: In the clinical setting, anticancer therapy is routinely administered to stimulate
programmed cell death or “apoptosis.” The goal is to eliminate tumor cells. Whether …

A common feature of cancer cells is their ability to evade apoptosis as a result of alterations
that block cell death signaling pathways. The extensive research efforts that elucidated …

Recent knowledge on apoptosis has made it possible to devise novel approaches, which
exploit this process to treat cancer. In this review, we discuss in detail approaches to induce …

Resistance towards apoptosis is a key factor for the survival of a malignant cell. Cancer
results if there is too little apoptosis and cells grow faster and live longer than normal cells. In …

Defective apoptosis (programmed cell death) represents a major causative factor in the
development and progression of cancer. The ability of tumor cells to evade engagement of …

Apoptosis in human cancer cells : Current Opinion in Oncology Apoptosis in human cancer
cells : Current Opinion in Oncology Log in or Register Subscribe to journalSubscribe Get new …

The majority of current anticancer therapies induce tumor cell death through the induction of
apoptosis. Alterations in the apoptotic pathways may determine tumor resistance to these …

One of the most important advances in cancer research in recent years is the recognition
that killing of tumor cells by anticancer therapies commonly used in the treatment of cancer …

Programmed cell death via apoptosis is characteristically disturbed in human cancers. This
facilitates not only tumor formation and progression, but also treatment resistance. Since …