In recent years, certain amphipathic, α-helical peptides have been discovered that inhibit
medically important enveloped viruses by disrupting the lipid membrane surrounding …

Using tethered sub-100 nm lipid vesicles that mimic enveloped viruses with nanoscale
membrane curvature, we have in this work designed a total internal reflection fluorescence …

An amphipathic α-helical (AH) peptide was recently discovered that can rupture the lipid
envelope of many viruses including HIV, hepatitis C, dengue, and herpes simplex. Despite …

Many medically important viruses are enveloped viruses, which are surrounded by a
structurally conserved, host-derived lipid membrane coating. Agents that target and disrupt …

Planar lipid bilayers on solid supports provide a controllable platform to mimic biological
membranes. Adsorption and spontaneous rupture of vesicles is the most common method to …

Membrane-enveloped viruses are a major cause of global health challenges, including
recent epidemics and pandemics. This mini-review covers the latest efforts to develop …

Conspectus The rapid growth in the global human population has increased the prevalence
of emerging infectious diseases, which poses a major risk to public health. In search of …

Molecules interfering with lipid bilayer function exhibit strong antiviral activity against a
broad range of enveloped viruses, with a lower risk of resistance development than that for …

The N-terminal region of the hepatitis C virus (HCV) nonstructural protein NS5A contains an
amphipathic α-helix that is necessary and sufficient for NS5A membrane association. A …

Understanding viral peptide detection and partitioning and the subsequent host membrane
composition-based response is essential for gaining insights into the viral mechanism. Here …