Quiescence is a fundamental property that maintains hematopoietic stem cell (HSC) potency
throughout life. Quiescent HSCs are thought to rely on glycolysis for their energy, but the …

Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on
anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy …

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …

Highlights•Specific modes of metabolism play important roles in hematopoietic stem cell
(HSC) self-renewal.•Heterogeneity and technical challenges have prevented the elucidation …

Despite efforts to understand and treat acute myeloid leukemia (AML), there remains a need
for more comprehensive therapies to prevent AML-associated relapses. To identify new …

Aging is associated with reduced fitness and increased myeloid bias of the hematopoietic
stem cell (HSC) compartment, causing increased risk of immune compromise, anemia, and …

Tissue homeostasis requires the presence of multipotent adult stem cells that are capable of
efficient self-renewal and differentiation; some of these have been shown to exist in a …

The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-
long production of blood cells. This process requires major molecular adaptations to allow …

Quiescent and self‐renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than
on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance …

The metabolic state of quiescent hematopoietic stem cells (HSCs) is an important regulator
of self-renewal, but it is unclear whether or how metabolic parameters contribute to HSC …