Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of prostaglandins (PGs)
and exists in two isoforms, COX-1 and COX-2. In spite of long-standing speculation …

Cyclooxygenase (COX)-derived prostaglandins are critical in female reproduction. Gene
targeting studies show that ovulation, fertilization, implantation, and decidualization are …

Cyclooxygenase-2 (COX-2), an inducible rate-limiting enzyme in prostaglandin
biosynthesis, is implicated in various physiological and pathological processes including …

Mice carrying a null mutation for either of the two cyclooxygenase (COX) isoenzymes,
necessary for prostanoid production, exhibit several isotype-specific reproductive …

Previous observations of ovulation and fertilization defects in cyclooxygenase-2 (COX-2)-
deficient mice suggested that COX-2-derived ovarian prostaglandins (PGs) participate in …

The infertility phenotype of cyclooxygenase-2 (Cox-2)-deficient female mice establishes the
important role of Cox-2 in pregnancy. Cox-2 deficiency results in defective ovulation …

Cyclooxygenase (COX)-derived prostaglandins (PGs) regulate numerous maternal–fetal
interactions during pregnancy. PGs stimulate uterine contractions and prepare the cervix for …

Cyclooxygenase (COX) is the rate-limiting enzyme in the biosynthesis of PGs. PGs together
with ovarian steroids play important regulatory roles in the establishment and maintenance …

Cyclo-oxygenase (COX) is a rate-limiting enzyme that converts arachidonic acid to
prostaglandins (PGs) and exists in two isoforms, COX-1 and COX-2. In the rodent, increased …

Prostaglandins (PGs) have been recently proven essential for parturition in mice. To dissect
the contributions of the two cyclooxygenase (COX) isoforms to the synthesis of PGs during …