Macroautophagy, an evolutionary conserved catabolic process in the eukaryotic cell,
regulates cellular homeostasis and plays a decisive role in self-engulfing proteins, protein …

Cellular quality control systems have gained much attention in recent decades. Among
these, autophagy is a natural self-preservation mechanism that continuously eliminates toxic …

The progressive aging of the population and the fact that Parkinson's disease currently does
not have any curative treatment turn out to be essential issues in the following years, where …

Converging evidence from genetic, pathological and experimental studies have increasingly
suggested an important role for autophagy impairment in Parkinson's Disease (PD). Genetic …

Autophagy is a cellular quality control mechanism crucial for neuronal homeostasis. Defects
in autophagy are critically associated with mechanisms underlying Parkinson´ s disease …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder that
affects about 1% of the population worldwide. Despite significant advances in the …

Autophagy is an essential catabolic mechanism that delivers misfolded proteins and
damaged organelles to the lysosome for degradation. Autophagy pathways include …

The most prevalent neurodegenerative disorders involve protein misfolding and the
aggregation of specific proteins. Autophagy is becoming an attractive target to treat …

Autophagy is the lysosome-mediated bulk degradation of cellular components for material
recycling to maintain cellular homeostasis. Autophagy was initially regarded as a …

Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of
lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part …