Timely and accurate RNA synthesis depends on accessory proteins that instruct RNA
polymerase (RNAP) where and when to start and stop transcription. Among thousands of …

In every cell from bacteria to mammals, NusG-like proteins bind transcribing RNA
polymerase to modulate the rate of nascent RNA synthesis and to coordinate it with …

The only universally conserved family of transcription factors comprises housekeeping
regulators and their specialized paralogs, represented by well-studied NusG and RfaH …

Nus factors are broadly conserved across bacterial species, and are often essential for
viability. A complex of five Nus factors (NusB, NusE, NusA, NusG and SuhB) is considered to …

Highlights•NusG/Spt5 is the only universally conserved transcription elongation
factor.•NusG/Spt5 recruits other elongation and termination factors to RNAP.•NusG …

NusA and NusG are major regulators of bacterial transcription elongation, which act either in
concert or antagonistically. Both bind to RNA polymerase (RNAP), regulating pausing as …

Transcription elongation factors from the NusG family are ubiquitous from bacteria to
humans and play diverse roles in the regulation of gene expression. These proteins consist …

Intrinsic transcription terminators consist of an RNA hairpin followed by a U-rich tract, and
these signals can trigger termination without the involvement of additional factors. Although …

Evolutionary related multisubunit RNA polymerases (RNAPs) transcribe the genomes of all
living organisms. Whereas the core subunits of RNAPs are universally conserved in all three …

In bacteria, transcription is coupled to, and can be regulated by, translation. Although recent
structural studies suggest that the N-utilization substance G (NusG) transcription factor can …