Background: Adiposity traits have been associated with risk of many cancers in
observational studies, but whether these associations are causal is unclear. Mendelian …

Abstract Background Observational and Mendelian randomization (MR) studies link obesity
and cancer, but it remains unclear whether these depend upon related metabolic …

Background Despite the established association between obesity and cancer risk, it remains
unclear whether visceral obesity is causally related to cancer risk and whether it is more pro …

Abstract Background Previous Mendelian randomization (MR) studies on obesity and risk of
breast cancer adopted a small number of instrumental variables and focused mainly on the …

Obesity and upper-body fat distribution are independent, cardiometabolic risk factors but
whether they also display comparable associations with cancer risk is unknown. We …

Associations of obesity have been established for at least 11 cancer sites in observational
studies, though some questions remain as to causality, strength of associations, and timing …

Obesity is considered a chronic inflammatory state characterized by continued secretion of
adipokines and cytokines. Experimental and epidemiological evidence indicates that …

Excess body adiposity, commonly expressed as body mass index (BMI), is a risk factor for
many common adult cancers. Over the past decade, epidemiological data have shown that …

Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

Obesity is associated with several types of cancer and fat distribution, which differs
dramatically between sexes, has been suggested to be an independent risk factor. However …