Gene therapy offers the potential of mediating disease through modification of specific
cellular functions of target cells. However, effective transport of nucleic acids to target cells …

Surface functionalization of theranostic nanoparticles (NPs) typically relies on lengthy,
aqueous postsynthesis labeling chemistries that have limited ability to fine-tune surface …

As conventional cancer therapies struggle with toxicity issues and irregular remedial
efficacy, the preparation of novel gene therapy vectors could offer clinicians the tools for …

A novel, efficient DNA delivery and transfection agent has been developed by chemically
attaching short chain polyethyleneimine (PEI) molecules (MW= 423 and 1800) to the surface …

Small‐interfering RNA (siRNA) is an emerging class of therapeutics, which works by
regulating the expression of a specific gene involved in disease progression. Despite the …

Gene-based therapies, including the delivery of oligonucleotides, offer promising methods
for the treatment of cancer cells. However, they have various limitations including low …

Gene therapy holds great promise for the treatment of acquired and inherited diseases. Non-
viral gene delivery systems are gaining recognition as alternatives to viral gene vectors due …

Poor water solubility and low transfection efficiency of chitosan are major drawbacks for its
use as a gene delivery carrier. PEGylation can increase its solubility, and folate conjugation …

Fe3O4 nanoparticles (NPs), the most traditional magnetic nanoparticles, have received a
great deal of attention in the biomedical field, especially for targeted drug/gene delivery …

We present the synthesis of dual-responsive (pH and temperature) magnetic core–shell
nanoparticles utilizing the grafting-from approach. First, oleic acid stabilized …