The advent of in vitro fertilization (IVF) in animals and humans implies an extraordinary
change in the environment where the beginning of a new organism takes place. In mammals …

ABSTRACT A vast array of successive epigenetic modifications ensures the creation of a
healthy individual. Crucial epigenetic reprogramming events occur during germ cell …

Developmental pathways in humans and other organisms are buffered against changes in
genotype and environment. Therefore, it should not come as a surprise that most of the …

Medically assisted reproductive technologies, such as in vitro embryo production, are
increasingly being used to palliate infertility. Eggs are produced following a hormonal …

Embryonic manipulation techniques, such as in vitro fertilization (IVF) and intracytoplasmic
sperm injection (ICSI), are widely used in assisted reproductive technology (ART), livestock …

The environment to which the mammalian embryo is exposed during the preimplantation
period of development has a profound effect on the physiology and viability of the …

Assisted reproduction technologies have been introduced 1) to overcome reproductive
failures in the human, 2) to increase the number of offspring from selected females and 3) to …

The foetal origins of adult diseases or Barker hypothesis suggests that there can be adverse
in uterus effects on the foetus that can lead to certain diseases in adults. Extending this …

The advent of the epigenetic era has sparked a new frontier in molecular research and the
understanding of how development can be regulated beyond direct alterations of the …

BACKGROUND Over the past few years, advances in molecular technologies have allowed
unprecedented mapping of epigenetic modifications in gametes and during early embryonic …