Background Protein engineering has many applications for industry, such as the
development of new drugs, vaccines, treatment therapies, food, and biofuel production. A …

The prediction of change in stability upon point mutations in proteins has many applications
in protein analysis and engineering. We recently adjoined a new structure-based method …

Here, we report a webserver for the improved SDM, used for predicting the effects of
mutations on protein stability. As a pioneering knowledge-based approach, SDM has been …

The NewProt protein engineering portal is a one-stop-shop for in silico protein engineering.
It gives access to a large number of servers that compute a wide variety of protein structure …

Background Many newly detected point mutations are located in protein-coding regions of
the human genome. Knowledge of their effects on the protein's 3D structure provides insight …

Computational grafting of target residues onto existing protein scaffolds is a powerful
method for the design of proteins with novel function. In the grafting method side chain …

The possible effects of mutations on stability and function of a protein can only be
understood in the context of protein 3D structure. The MutationExplorer webserver maps …

Motivation: There is a need for an efficient and accurate computational method to identify the
effects of single-and multiple-residue mutations on the stability and reactivity of proteins …

PoPMuSiC is an efficient tool for rational computer-aided design of single-site mutations in
proteins and peptides. Two types of queries can be submitted. The first option allows to …

We have developed a method to both predict the geometry and the relative stability of point
mutants that may be used for arbitrary mutations. The geometry optimization procedure was …