Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.
C van Genderen, RM Okamura, I Farinas… - Genes & …, 1994 - genesdev.cshlp.org
Lymphoid enhancer factor 1 (LEF-1) is a sequence-specific DNA-binding protein that is
expressed in pre-B and T lymphocytes of adult mice, and in the neural crest …
expressed in pre-B and T lymphocytes of adult mice, and in the neural crest …
Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development.
K Kratochwil, M Dull, I Farinas, J Galceran… - Genes & …, 1996 - genesdev.cshlp.org
Targeted inactivation of the murine gene encoding the transcription factor LEF-1 abrogates
the formation of organs that depend on epithelial-mesenchymal tissue interactions. In this …
the formation of organs that depend on epithelial-mesenchymal tissue interactions. In this …
FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1−/− mice
K Kratochwil, J Galceran, S Tontsch… - Genes & …, 2002 - genesdev.cshlp.org
Lymphoid enhancer factor (LEF1), a nuclear mediator of Wnt signaling, is required for the
formation of organs that depend on inductive interactions between epithelial and …
formation of organs that depend on inductive interactions between epithelial and …
LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]
A Travis, A Amsterdam, C Belanger… - Genes & …, 1991 - genesdev.cshlp.org
Lymphoid-specific cDNA clones were isolated that encode a nuclear protein with homology
to the chromosomal nonhistone protein HMG-1 and to putative regulators of cell …
to the chromosomal nonhistone protein HMG-1 and to putative regulators of cell …
The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing
K Hovanes, TWH Li, ML Waterman - Nucleic acids research, 2000 - academic.oup.com
Abstract Lymphoid Enhancer Factor-1 (LEF-1) is a member of a family of transcription factors
that function as downstream mediators of the Wnt signal transduction pathway. In the …
that function as downstream mediators of the Wnt signal transduction pathway. In the …
DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1.
K Giese, A Amsterdam, R Grosschedl - Genes & development, 1991 - genesdev.cshlp.org
Lymphoid enhancer-binding factor 1 (LEF-1) is a pre-B and T lymphocyte-specific nuclear
protein that participates in the regulation of the T-cell antigen receptor (TCR) alpha …
protein that participates in the regulation of the T-cell antigen receptor (TCR) alpha …
LEF‐1 contains an activation domain that stimulates transcription only in a specific context of factor‐binding sites.
K Giese, R Grosschedl - The EMBO journal, 1993 - embopress.org
Lymphoid enhancer factor 1 (LEF‐1) is a member of the high mobility group (HMG) family of
proteins and participates in the regulation of the T cell receptor (TCR) alpha enhancer. We …
proteins and participates in the regulation of the T cell receptor (TCR) alpha enhancer. We …
[PDF][PDF] Tcf/Lef transcription factors during T-cell development: unique and overlapping functions
The founding members of the TCF family are T-cell factor-1 (Tcf-1) and lymphoid enhancing
factor-1 (Lef-1). In adult mammals, Tcf-1 is uniquely expressed in T lymphocytes, while Lef-1 …
factor-1 (Lef-1). In adult mammals, Tcf-1 is uniquely expressed in T lymphocytes, while Lef-1 …
LFB3, a heterodimer‐forming homeoprotein of the LFB1 family, is expressed in specialized epithelia.
V De Simone, L De Magistris, D Lazzaro… - The EMBO …, 1991 - embopress.org
We have cloned and characterized a mouse cDNA coding for LFB3, a DNA binding protein
containing an extra‐large homeodomain. The first 315 amino acids of LFB3 are highly …
containing an extra‐large homeodomain. The first 315 amino acids of LFB3 are highly …
Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis
M Oosterwegel, M van de Wetering… - …, 1993 - journals.biologists.com
The recent identification of a number of T lymphocytespecific enhancers has allowed the
cloning of several novel transcription factors. Two of these, TCF-1 and LEF-1, contain a …
cloning of several novel transcription factors. Two of these, TCF-1 and LEF-1, contain a …