Simple Summary Effective cancer treatment hinges upon overcoming therapeutic resistance
mechanisms that allow for the continued proliferation of cancer cell subpopulations …

Simple Summary Lung cancer is still the most common cause of cancer death, worldwide
with increasing incidence. In lung cancer management, chemotherapy alone, or combined …

Chemoresistance is a major problem in cancer therapy as cancer cells develop mechanisms
that counteract the effect of chemotherapeutic compounds, leading to relapse and the …

A frequent observation in several malignancies is the development of resistance to therapy
that results in frequent tumor relapse and metastasis. Much of the tumor resistance …

Notwithstanding cancer patients benefit from a plethora of therapeutic alternatives, drug
resistance remains a critical hurdle. Indeed, the high mortality rate is associated with …

Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Chemoresistance, tumor progression, and metastasis are features that are frequently seen
in cancer that have been associated with cancer stem cells (CSCs). These cells are a …

Cancer stem cells (CSCs) or cancer initiating cells are a subpopulation of cells that has the
driving force of carcinogenesis. They exhibit distinctive self-renewal, proliferation, and …

In the absence of specific treatable mutations, platinum-based chemotherapy remains the
gold standard of treatment for lung cancer patients. However, 5-year survival rates remain …

Lung cancer is the leading cause of cancer mortality worldwide. Despite advances in anti-
cancer therapies such as chemotherapy, radiotherapy and targeted therapies, five-year …