[HTML][HTML] MicroRNA-21 knockout improve the survival rate in DSS induced fatal colitis through protecting against inflammation and tissue injury
C Shi, Y Liang, J Yang, Y Xia, H Chen, H Han, Y Yang… - PloS one, 2013 - journals.plos.org
Background MicroRNA-21 (miR-21) is overexpressed in most inflammatory diseases, but its
physiological role in gut inflammation and tissue injury is poorly understood. The goal of this …
physiological role in gut inflammation and tissue injury is poorly understood. The goal of this …
MicroRNA-31 reduces inflammatory signaling and promotes regeneration in colon epithelium, and delivery of mimics in microspheres reduces colitis in mice
Background & Aims Levels of microRNA 31 (MIR31) are increased in intestinal tissues from
patients with inflammatory bowel diseases and colitis-associated neoplasias. We …
patients with inflammatory bowel diseases and colitis-associated neoplasias. We …
Loss of microRNA-21 influences the gut microbiota, causing reduced susceptibility in a murine model of colitis
Background and Aims microRNAs regulate gene expression and influence the
pathogenesis of human diseases. The present study investigated the role of microRNA-21 …
pathogenesis of human diseases. The present study investigated the role of microRNA-21 …
[HTML][HTML] miR-26a attenuates colitis and colitis-associated cancer by targeting the multiple intestinal inflammatory pathways
W Zhang, X Fu, J Xie, H Pan, W Han… - Molecular Therapy-Nucleic …, 2021 - cell.com
Patients with inflammatory bowel disease are at increased risk for colitis-associated
colorectal cancer (CAC). Therefore, controlling intestinal inflammation is a key therapeutic …
colorectal cancer (CAC). Therefore, controlling intestinal inflammation is a key therapeutic …
Role of miR-19a targeting TNF-α in mediating ulcerative colitis
B Chen, S She, D Li, Z Liu, X Yang… - Scandinavian journal of …, 2013 - Taylor & Francis
Objective. Ulcerative colitis (UC) is a widely studied inflammatory disease associated with
differential expression of genes involved in immune function, wound healing, and tissue …
differential expression of genes involved in immune function, wound healing, and tissue …
MicroRNA-125a suppresses intestinal mucosal inflammation through targeting ETS-1 in patients with inflammatory bowel diseases
Y Ge, M Sun, W Wu, C Ma, C Zhang, C He, J Li… - Journal of …, 2019 - Elsevier
Abstract MicroRNA (miR)-125a is highly expressed in T cells and regulates the functions of
Treg through the IL-6-STAT3 signaling pathway. However, the role of miR-125a in regulating …
Treg through the IL-6-STAT3 signaling pathway. However, the role of miR-125a in regulating …
[HTML][HTML] MiR-29a promotes intestinal epithelial apoptosis in ulcerative colitis by down-regulating Mcl-1
B Lv, Z Liu, S Wang, F Liu, X Yang, J Hou… - … Journal of Clinical …, 2014 - ncbi.nlm.nih.gov
Objective: While it's widely accepted that the etiology of ulcerative colitis (UC) involves both
genetic and environmental factors, the pathogenesis of ulcerative colitis is still poorly …
genetic and environmental factors, the pathogenesis of ulcerative colitis is still poorly …
[HTML][HTML] Suppression of microRNA-222-3p ameliorates ulcerative colitis and colitis-associated colorectal cancer to protect against oxidative stress via targeting BRG1 …
X Wang, D Zhang, Y Yang, X Li, H Li, X Zhang… - Frontiers in …, 2023 - frontiersin.org
Oxidative stress is an important pathogenic factor in ulcerative colitis (UC) and colitis-
associated colorectal cancer (CAC), further impairing the entire colon. Intestinal epithelial …
associated colorectal cancer (CAC), further impairing the entire colon. Intestinal epithelial …
[HTML][HTML] miR-19b downregulates intestinal SOCS3 to reduce intestinal inflammation in Crohn's disease
X Cheng, X Zhang, J Su, Y Zhang, W Zhou, J Zhou… - Scientific reports, 2015 - nature.com
Although aberrant microRNA (miRNA) expression has frequently been observed in
inflammatory bowel disease (IBD), its biological functions and targets remain largely …
inflammatory bowel disease (IBD), its biological functions and targets remain largely …
Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer
C Shi, Y Yang, Y Xia, Y Okugawa, J Yang, Y Liang… - Gut, 2016 - gut.bmj.com
Objective miR-21 was found to be overexpressed in the colon tissues and serum of patients
with UC and colorectal cancer (CRC); however, the exact roles of miR-21 in colitis …
with UC and colorectal cancer (CRC); however, the exact roles of miR-21 in colitis …