The drastic intestinal secretion of fluid and electrolytes that is characteristic of cholera is the
result of reasonably well understood cellular and biochemical actions of the toxin secreted …

Only during the past decade has it become widely accepted that the primary
pathophysiological changes in cholera are caused by a soluble exotoxin elaborated by …

THE treatment of cholera by intravenous fluids and electrolytes is well established and, if
instituted before dehydration and shock are irreversible, can completely protect the patient …

Cholera toxin is a protein isolated from the culture filtrate of Vibrio choleraeas the causative
agent of diarrhea in experimental animals. This protein has attracted considerable attention …

Cholera toxin was obtained in pure form by fractionation on two phosphocellulose columns
successively. Cholera toxin and choleragenoid were quantitatively and selectively adsorbed …

Live oral candidate cholera vaccines have previously been constructed by deletion of Vibrio
cholerae sequences encoding the enzymatically active A subunit of the cholera toxin …

It is generally accepted that the intestinal manifestations of cholera are due to the action of
endotoxin of Vibrio comma and that the question as to what extent this endotoxin is …

The bacterial protein toxin of Vibrio cholerae, cholera toxin, is a major agent involved in
severe diarrhoeal disease. Cholera toxin is a member of the AB toxin family and is …

Immunohistochemical techniques, done with fluorescein-and horseradish peroxidase-
labeled antibodies specifically purified by immunoadsorption, were used to show cholera …

Environmental and nontoxigenic strains of Vibrio cholerae 0-1 were examined for genes
homologous to genes encoding Escherichia coli heat-labile enterotoxin (LT). Restriction …