The efficiency of central nervous system remyelination declines with age. This is in part due
to an age-associated decline in the phagocytic removal of myelin debris, which contains …

The molecular basis of CNS myelin regeneration (remyelination) is poorly understood. We
generated a comprehensive transcriptional profile of the separate stages of spontaneous …

Background and Purpose—Phagocytic cells, such as microglia and blood-derived
macrophages, are a key biological modality responsible for phagocytosis-mediated …

Bexarotene, a retinoid X receptor (RXR) agonist, is approved by FDA to treat cutaneous T-
cell lymphoma. However, it has also demonstrated promising therapeutic potential for …

Alzheimer's disease (AD) is characterized by extensive neuron loss that accompanies
profound impairments in memory and cognition. We examined the neuronally directed …

Background Progressive disability in multiple sclerosis occurs because CNS axons
degenerate as a late consequence of demyelination. In animals, retinoic acid receptor RXR …

Apolipoprotein E (apoE) plays a critical role in maintaining synaptic integrity by transporting
cholesterol to neurons through the low-density lipoprotein receptor related protein-1 (LRP1) …

Alzheimer's disease (AD) is characterized by a robust inflammatory response elicited by the
accumulation and subsequent deposition of amyloid (Aβ) within the brain. The brain's …

Bexarotene-activated retinoid X receptors (RXRs) ameliorate memory deficits in Alzheimer's
disease mouse models, including mice expressing human apolipoprotein E (APOE) …

Although commonly considered a disease of white matter, gray matter demyelination is
increasingly recognized as an important component of multiple sclerosis (MS) pathogenesis …