Abstract Background The Werner syndrome protein (WRN) belongs to the RecQ family of
helicases and its loss of function results in the premature aging disease Werner syndrome …

The Werner syndrome protein (WRN) is a nuclear protein required for cell growth and
proliferation. Loss‐of‐function mutations in the Werner syndrome gene are associated with …

Werner syndrome (WS) is an excellent model system for the study of human aging. WRN, a
nuclear protein mutated in WS, plays multiple roles in DNA metabolism. Our understanding …

Werner syndrome (WS) is a premature aging and cancer-prone disease caused by loss of
the RecQ helicase WRN protein. Cultured WS fibroblasts display high genomic instability …

Mutations in genes for WRN and BLM RecQ family helicases cause cancer prone
syndromes. Werner syndrome, resulting from WRN mutation, is a segmental progeria …

The WRN RECQ helicase is responsible for the Werner syndrome of premature aging and
cancer predisposition. Substantial progress has been made in delineating WRN functions in …

Werner syndrome (WS), caused by mutation of the WRN gene, is an autosomal recessive
disorder associated with premature aging and predisposition to cancer. WRN belongs to the …

Werner syndrome (WS) is an inherited disorder characterized by premature onset of aging,
genomic instability, and increased cancer incidence. The disease is caused by loss of …

Werner syndrome (WS) is a rare autosomal recessive genetic disorder causing premature
aging and rare cancers. A gene responsible for WS (WRN) encodes a protein with 1432 …

Werner syndrome (WS) is characterized by the premature onset of several age-associated
pathologies. The protein deficient in WS (WRN) is a RecQ-type DNA helicase involved in …