Abstract Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are
essential for normal lymphoid development. In their absence, severe combined …

Interleukin-7 (IL-7), a cytokine produced in the bone marrow, thymus and other organs, is
mandatory for normal human T-cell development and peripheral homeostasis. Different …

The cytokine interleukin-7 (IL-7) and its receptor are critical for lymphoid cell development.
The loss of IL-7 signaling causes severe combined immunodeficiency, whereas gain-of …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy
resulting from the dysregulation of signaling pathways that control intrathymic T-cell …

The purposes of this study were to examine the biologic effects of the engagement of the
interleukin-7 receptor (IL-7R) with recombinant human interleukin-7 (rhIL-7) in …

The importance of microenvironmental factors for driving progression in leukemia has been
debated. Previous evidence has pointed to interleukin-7 (IL-7), a fundamental cytokine to …

Tight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-
of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL) …

The malignant transformation and expansion of tumor cells involve both cell-autonomous
mechanisms and microenvironment signals that regulate viability, nutrient utilization …

T-cell acute lymphoblastic leukemia (T-ALL) constitutes an aggressive subset of ALL, the
most frequent childhood malignancy. Whereas interleukin-7 (IL-7) is essential for normal T …

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk
subtype of B-ALL often associated with genetic variants that alter cytokine receptor …