Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota

AE Lindell, M Zimmermann-Kogadeeva… - Nature Reviews …, 2022 - nature.com
The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …

Antibiotic effects on gut microbiota, metabolism, and beyond

C Mu, W Zhu - Applied microbiology and biotechnology, 2019 - Springer
Current advances on gut microbiota have broadened our view on host-microbiota
interactions. As a microbiota-targeted approach, the use of antibiotics has been widely …

Xenobiotics: interaction with the intestinal microflora

K Lu, R Mahbub, JG Fox - ILAR journal, 2015 - academic.oup.com
The human body is host to 100 trillion gut microbes, approximately 10-times more than all
human cells. It is estimated that the approximately 500–1000 species residing in the human …

Systematically investigating the impact of medication on the gut microbiome

L Maier, A Typas - Current opinion in microbiology, 2017 - Elsevier
Highlights•Association studies report drug-mediated changes in microbiome signatures.•
Interactions with the microbiome can be part of a drug's mode of action or side effects.• …

Gut microorganisms, mammalian metabolism and personalized health care

JK Nicholson, E Holmes, ID Wilson - Nature Reviews Microbiology, 2005 - nature.com
The mammalian gut microbiota interact extensively with the host through metabolic
exchange and co-metabolism of substrates. Such metabolome–metabolome interactions are …

[HTML][HTML] Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics

RN Carmody, PJ Turnbaugh - The Journal of clinical …, 2014 - Am Soc Clin Investig
Our associated microbial communities play a critical role in human health and predisposition
to disease, but the degree to which they also shape therapeutic interventions is not well …

Chemical communication in the gut: Effects of microbiota-generated metabolites on gastrointestinal bacterial pathogens

SL Vogt, J Peña-Díaz, BB Finlay - Anaerobe, 2015 - Elsevier
Gastrointestinal pathogens must overcome many obstacles in order to successfully colonize
a host, not the least of which is the presence of the gut microbiota, the trillions of commensal …

Integrating the gut microbiome and pharmacology

AA Verdegaal, AL Goodman - Science Translational Medicine, 2024 - science.org
The gut microbiome harbors trillions of organisms that contribute to human health and
disease. These bacteria can also affect the properties of medical drugs used to treat these …

Interaction between drugs and the gut microbiome

RK Weersma, A Zhernakova, J Fu - Gut, 2020 - gut.bmj.com
The human gut microbiome is a complex ecosystem that can mediate the interaction of the
human host with their environment. The interaction between gut microbes and commonly …

[HTML][HTML] Gut microbiota as an “invisible organ” that modulates the function of drugs

X Li, L Liu, Z Cao, W Li, H Li, C Lu, X Yang… - Biomedicine & …, 2020 - Elsevier
Gut microbiota plays an important role in the gut and have become a hotspot of recent
research interests. Commensal microbiota in gut exert a variety of effects on the host, from …